Effect of culture medium and carbon dioxide concentration on growth of anaerobic bacteria and medium pH. 1986

J E Jansen, and A Bremmelgaard

Two Danish agars, Danish Blood Agar (D.B.A.) and Anaerobic Agar (A.A.), were evaluated for their ability to support growth of 47 clinically isolated anaerobic strains in 5 different CO2-concentrations ranging from 0-10% CO2. CO2 and the use of an enriched medium (A.A.) are essential for satisfactory recovery of anaerobes. No gain could be seen when raising the CO2-concentration above 5%. The surface pH of the agars was measured both on non-inoculated and inoculated plates at room temperature and anaerobic incubation in the 5 different CO2-concentrations at 37 degrees C. Temperature change from room temperature to 37 degrees C resulted in a pH decrease of 0.1 units. There was a CO2-mediated decrease in pH (approximately 0.05 units/pr. CO2%) on non-inoculated media. On inoculated plates there was a minor additional fall in pH, which increased with time of incubation, but first became significant when the plates were incubated for more than 24 h. The use of 5% CO2 and A.A. is recommended for antimicrobial susceptibility studies on solid media.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D002245 Carbon Dioxide A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D001421 Bacteria, Anaerobic Bacteria that can survive and grow in the complete, or nearly complete absence of oxygen. Anaerobic Bacteria
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures

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