-transparent.png){kind=logo}
Conjugates of the chelating agents DTPA and TTHA with a monoclonal anti-HCG were prepared. The tissue distribution of the 111In-labeled conjugates and also 111In-citrate was studied in mice bearing human choriocarcinoma xenografts. The antibody conjugates both gave high liver and spleen radionuclide accumulation. Elevated femur levels were observed for the TTHA conjugate and 111In-citrate. Generally the DTPA conjugate showed the highest tumor/tissue ratios, although its tumor/blood ratio was lower than the other two materials. The results infer that the DTPA conjugate has the greatest utility as an imaging agent but that it would require a background subtraction technique.
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
February 1999,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
March 1992,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
January 2010,
Human antibodies,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
July 1995,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
August 2004,
Cancer biotherapy & radiopharmaceuticals,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
February 1990,
Cancer research,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
June 1987,
Cancer research,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
November 1986,
Nuclear medicine communications,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
January 1988,
European journal of nuclear medicine,
R G Buckley, and
P Barnett, and
F Searle, and
R Pedley, and
J A Boden
January 2008,
Bioconjugate chemistry,
