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Successful hematopoietic stem-cell mobilization with plerixafor plus granulocyte-colony stimulating factor in multiple myeloma patients treated with pomalidomide. 2019
Kota Yoshifuji, and
Takashi Toya, and
Hiroto Adachi, and
Masahiro Fujita, and
Atsushi Wada, and
Ryosuke Konuma, and
Yuya Kishida, and
Tatsuya Konishi, and
Akihito Nagata, and
Yuta Yamada, and
Satoshi Kaito, and
Takuma Kumagai, and
Kyoko Inamoto, and
Megumi Akiyama, and
Aiko Igarashi, and
Yuho Najima, and
Noriko Doki, and
Takeshi Kobayashi, and
Kazuhiko Kakihana, and
Hisashi Sakamaki, and
Kazuteru Ohashi
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
Autologous stem-cell transplantation is an effective procedure for the treatment of multiple myeloma, and involves the collection of hematopoietic stem cells (HSCs). However, in some patients, HSCs in the bone marrow fail to mobilize. Pomalidomide upregulates CXCR4 in hematopoietic stem cells, in a manner similar to that of lenalidomide, and is, thus, likely to have a negative impact on hematopoietic stem-cell mobilization in multiple myeloma patients. Here, we report the two cases in which hematopoietic stem cells were mobilized using plerixafor plus granulocyte-colony stimulating factor after exposure to lenalidomide and pomalidomide. Use of plerixafor with a sufficient washout period may lead to successful mobilization following pomalidomide use, although further study of this potential use is needed.
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