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The distribution and identity of Thy-1+ cells during ontogeny in the rat were examined by immunofluorescent and histologic techniques, and the relative amount of Thy-1 antigen on different cell types was assessed by quantitative absorption. Thy-1+ cells were subsequently studied by dual immunofluorescence for the simultaneous expression of either T or B lymphocyte markers. The results indicate that the Thy-1 antigen is present on hemopoietic precursors and on at least some of their lymphoid (both T and B) and nonlymphoid descendants. In addition, six serologically distinct subpopulations of lymphoid cells were identified, and their position in T and B cell maturational pathways is discussed.
M A Ritter, and
L K Gordon, and
I Goldschneider
October 1993,
Transplantation proceedings,
M A Ritter, and
L K Gordon, and
I Goldschneider
June 1985,
Journal of immunology (Baltimore, Md. : 1950),
M A Ritter, and
L K Gordon, and
I Goldschneider
February 1986,
Laboratory investigation; a journal of technical methods and pathology,
M A Ritter, and
L K Gordon, and
I Goldschneider
November 1978,
The Journal of experimental medicine,
M A Ritter, and
L K Gordon, and
I Goldschneider
October 2002,
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M A Ritter, and
L K Gordon, and
I Goldschneider
May 1981,
Neurochemical research,
M A Ritter, and
L K Gordon, and
I Goldschneider
March 1981,
Journal of immunology (Baltimore, Md. : 1950),
M A Ritter, and
L K Gordon, and
I Goldschneider
January 1987,
Archives of oral biology,
M A Ritter, and
L K Gordon, and
I Goldschneider
April 1993,
European journal of immunology,
M A Ritter, and
L K Gordon, and
I Goldschneider
November 1998,
Development (Cambridge, England),
