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The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulators of protein kinase C. This effect occurred within minutes, was concentration dependent, and exhibited the appropriate pharmacological specificity to attribute the effects to protein kinase C. Phorbol myristate acetate (PMA), phorbol dibutyrate (PDB) and teleocidin were active with appropriate EC50's, while 4-alpha-PMA was inactive. PMA and PDB were also ACTH secretagogues in their own right. We suggest that protein kinase C can modulate CRF receptor coupling to the adenylate cyclase holoenzyme in anterior pituitary cells.
M J Cronin, and
J R Zysk, and
A J Baertschi
January 1990,
Peptides,
M J Cronin, and
J R Zysk, and
A J Baertschi
October 1986,
The Journal of biological chemistry,
M J Cronin, and
J R Zysk, and
A J Baertschi
November 1982,
Endocrinology,
M J Cronin, and
J R Zysk, and
A J Baertschi
January 1985,
Peptides,
M J Cronin, and
J R Zysk, and
A J Baertschi
January 1985,
Nature,
M J Cronin, and
J R Zysk, and
A J Baertschi
July 1969,
Biochemical and biophysical research communications,
M J Cronin, and
J R Zysk, and
A J Baertschi
June 1985,
Biochemical and biophysical research communications,
M J Cronin, and
J R Zysk, and
A J Baertschi
January 1978,
Transactions of the Association of American Physicians,
M J Cronin, and
J R Zysk, and
A J Baertschi
June 1982,
Proceedings of the National Academy of Sciences of the United States of America,
M J Cronin, and
J R Zysk, and
A J Baertschi
January 1984,
Neurochemical research,
