-transparent.png){kind=logo}
5-(2,4-Difluorophenyl)salicylic acid, diflunisal (25), is the best compound, in terms of both efficacy and safety, from over 500 salicylates investigated in our laboratories. It is a chemically distinct, nonacetylating salicylic acid, more active than aspirin as an analgesic and antiinflammatory agent and superior in duration of action and therapeutic index. Some recent clinical and biochemical observations are briefly discussed.
Related Publications
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
January 1994,
Arthritis and rheumatism,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
April 1990,
Dental management,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
June 2001,
Anesthesiology,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
November 1974,
Tandlaegebladet,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
May 1983,
Heart & lung : the journal of critical care,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
September 1984,
British medical journal (Clinical research ed.),
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
June 1957,
The New England journal of medicine,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
February 2014,
Food & function,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
January 1978,
Bioinorganic chemistry,
J Hannah, and
W V Ruyle, and
H Jones, and
A R Matzuk, and
K W Kelly, and
B E Witzel, and
W J Holtz, and
R A Houser, and
T Y Shen, and
L H Sarett
June 1987,
Dental management,
