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A chemosensitivity test for UFT and FT-207, which are used in long-term administration clinically, was investigated for prediction of clinical response. Five transplantation-established human tumor xenograft systems were examined using subrenal capsule assay. Both anticancer agents showed antiproliferative effects according to the total administered dose. Two of 5 tumors were determined to be sensitive to UFT using microscopic measurements following intragastric administration of 1/2 of the LD50 value, while they were shown to be resistant to 5-FU. In these two cases, prolongation of life span by long-term administration of UFT was shown clinically. All these experiments could be performed on condition that the loss of body weight in mice was less than 20%. These results suggest that in the 4-day subrenal capsule assay, clinical responses to long-term administration of UFT or FT-207 are predictable using intragastric high-dose administration which does not induce more than 20% body weight loss in experimental mice.
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July 1990,
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T Hattori
May 1988,
Nihon Gan Chiryo Gakkai shi,
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T Hattori
April 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
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June 1989,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
M Nishiyama, and
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N Hirabayashi, and
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T Tohge, and
M Niimoto, and
T Hattori
August 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Nishiyama, and
K Niimi, and
M Yamaguchi, and
N Hirabayashi, and
Y Nosoh, and
T Tohge, and
M Niimoto, and
T Hattori
March 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Nishiyama, and
K Niimi, and
M Yamaguchi, and
N Hirabayashi, and
Y Nosoh, and
T Tohge, and
M Niimoto, and
T Hattori
January 1992,
Nihon Jibiinkoka Gakkai kaiho,
M Nishiyama, and
K Niimi, and
M Yamaguchi, and
N Hirabayashi, and
Y Nosoh, and
T Tohge, and
M Niimoto, and
T Hattori
December 1991,
Journal of UOEH,
M Nishiyama, and
K Niimi, and
M Yamaguchi, and
N Hirabayashi, and
Y Nosoh, and
T Tohge, and
M Niimoto, and
T Hattori
June 1989,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
M Nishiyama, and
K Niimi, and
M Yamaguchi, and
N Hirabayashi, and
Y Nosoh, and
T Tohge, and
M Niimoto, and
T Hattori
January 1987,
Oncology,
