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In order to assess the role of arachidonic acid metabolites in the early reaction to antigen, we challenged six allergic individuals with and without premedication with aspirin and recorded their clinical response, as indicated by number of sneezes, and measured the levels of inflammatory mediators. The early reaction to antigen was associated with increases in the levels of histamine, N-alpha-tosyl-L-arginine methyl esterase (TAME-esterase) activity, prostaglandin (PG) D2, leukotriene C4, PGE, and thromboxane. Aspirin significantly inhibited the increases in the cyclooxygenase metabolites PGE, PGD2, PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane but did not affect the amount of sneezing or the levels of histamine, TAME-esterase activity, or leukotrienes. The pattern of the metabolites and their response to pretreatment with aspirin parallel the response of purified human lung mast cells, supporting the notion that the early phase of allergic rhinitis is a mast cell-dominated event.
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
January 1993,
Acta oto-laryngologica. Supplementum,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
January 1986,
New England and regional allergy proceedings,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
February 1987,
The Laryngoscope,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
January 1984,
Bibliotheca cardiologica,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
September 1983,
Clinical reviews in allergy,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
April 1985,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
November 1991,
Prostaglandins,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
December 1989,
Scandinavian journal of gastroenterology,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
June 2000,
Acta oto-laryngologica,
M S Brown, and
S P Peters, and
N F Adkinson, and
D Proud, and
A Kagey-Sobotka, and
P S Norman, and
L M Lichtenstein, and
R M Naclerio
May 1982,
Klinische Wochenschrift,
