To present clinical application of fluorescein angiography (FA)-free focal laser photocoagulation (FLP) of the leakage point in patients with central serous chorioretinopathy (CSC). A prospective case series included 16 eyes of 16 patients with non-resolved CSC. The leakage point was identified with optical coherence tomography (OCT) as a small single pigment epithelium detachment (PED) localized in the upper half of the neurosensory detachment with an area of photoreceptor outer segments layer thinning above this PED. FLP was performed with the Navilas 532 system. All patients achieved complete resolution of the subretinal fluid within a mean time of 6.5 ± 1.8 weeks. The mean best-corrected visual acuity statistically significantly increased from 0.08 ± 0.09 (20/25) at baseline to 0.0 ± 0.04 (20/20) at 2 months after FLP (P = .0005). FA-free, OCT-guided navigated FLP is an effective and safe option to treat a significant number of patients with CSC. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e118-e124.].