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Immuno-isoelectric focusing (IIEF) showed a 61% incidence of serum paraproteinaemia in 56 patients with chronic lymphocytic leukaemia (CLL). A strong correlation between the serum paraprotein heavy chain isotypes and those of the cytoplasmic heavy chain immunoglobulins was observed with no discrepancy noted in light chain expression. Density gradient ultracentrifugation analysis of selected sera containing monoclonal IgM showed that the IgM paraproteins were mostly 19S, secretory IgM but one patient was found to have both 19S and 8S monoclonal IgM. When the cellular origin of the IgM and IgD paraproteins found in one patient was investigated, both paraproteins were found to share the same idiotype and originate from the neoplastic clone. These findings confirm the view that there is an incomplete maturation block in chronic lymphocytic leukaemia and that in vivo secretion of paraproteins by the neoplastic cells is a relatively common occurrence.
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
September 1988,
British journal of haematology,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
August 1978,
Lancet (London, England),
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
September 2020,
British journal of haematology,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
January 1971,
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D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
February 1986,
British journal of haematology,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
July 2022,
British journal of haematology,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
September 1997,
Blood reviews,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
April 1996,
British journal of haematology,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
April 2012,
Leukemia research,
D Sinclair, and
J H Dagg, and
A E Dewar, and
A M Mowat, and
D M Parrott, and
G Stockdill, and
D I Stott
January 1989,
Annales de genetique,
