Biomaterial Database

Does brain-derived neurotrophic factor mediate the effects of exercise on memory? 2019

Paul D Loprinzi

Exercise & Memory Laboratory, Department of Health, Exercise Science and Recreation Management, University of Mississippi, University, MS, USA.

Objective: Brain-derived neurotrophic factor (BDNF) has been hypothesized as a potential mechanism through which exercise may subserve memory function. The present review specifically evaluates this hypothesis.Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar.Results: In total, 52 articles met the study criteria, and among these, 36 were conducted in an animal model and 16 among humans. Among the animal experiments, 100% of them demonstrated that chronic exercise improved memory function; 97% demonstrated an exercise-induced increase in BDNF; and among the eight evaluating BDNF as a mediator, 100% provided evidence that BDNF mediated the relationship between exercise and memory. The findings in the human studies were mixed. Among the human studies, 44% demonstrated that varying exercise protocols improved memory and increased BDNF levels, and among the studies evaluating BDNF as a mediator, 40% provided evidence that BDNF mediated the relationship between exercise and memory.Conclusion: In animal models, chronic exercise training robustly increases BDNF and improves memory performance, with reasonable evidence to also suggest that BDNF may mediate the exercise-memory interaction. These interrelationships, however, are less clear among humans. Future research among humans, in particular, is needed to evaluate the extent to which BDNF may mediate the relationship between exercise and memory.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008568	Memory	Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D003071	Cognition	Intellectual or mental process whereby an organism obtains knowledge.	Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015444	Exercise	Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.	Aerobic Exercise,Exercise, Aerobic,Exercise, Isometric,Exercise, Physical,Isometric Exercise,Physical Activity,Acute Exercise,Exercise Training,Activities, Physical,Activity, Physical,Acute Exercises,Aerobic Exercises,Exercise Trainings,Exercise, Acute,Exercises,Exercises, Acute,Exercises, Aerobic,Exercises, Isometric,Exercises, Physical,Isometric Exercises,Physical Activities,Physical Exercise,Physical Exercises,Training, Exercise,Trainings, Exercise
D019208	Brain-Derived Neurotrophic Factor	A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)	BDNF,Brain Derived Neurotrophic Factor,Factor, Brain-Derived Neurotrophic,Neurotrophic Factor, Brain-Derived