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Intracisternal injection of blood in the rat induces an angiographically demonstrable, biphasic cerebral vasospasm of the vertebrobasilar system, with a maximal acute spasm at 10 min and a maximal late spasm at 2 days after the subarachnoid hemorrhage (SAH). Selective lesioning of the A1 nuclei in the medulla oblongata prior to the SAH prevents the development of the late spasm, but the acute spasm develops to the same extent as in sham-lesioned animals. Lesions of the medullary A2 nuclei not only prevent the development of both acute and late spasm, but give rise to a dilatation of the vertebrobasilar arteries at day 2 post-SAH. The study indicates that both the A1 and A2 nuclei participate in the development of vasospasm post-SAH. The contrasting patterns of spasm after A1 and A2 lesions suggest a different mechanism for acute and late spasm.
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
December 1986,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
January 1985,
Stroke,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
January 1984,
Stroke,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
October 1974,
Journal of neurosurgery,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
January 2017,
Turkish neurosurgery,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
February 1993,
Neurosurgery,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
March 1979,
Neuropharmacology,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
March 1985,
Neurological research,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
January 1982,
Acta neurochirurgica,
N A Svendgaard, and
M A Arbab, and
T J Delgado, and
E Rosengren
July 1986,
Japanese journal of pharmacology,
