-transparent.png){kind=logo}
Glycogen synthase was partially purified from canine brain to about 70% purity. The purified enzyme showed differences from the properties of the skeletal muscle enzyme with respect to molecular weights of the holoenzyme and subunit and phosphopeptide mapping. The multifunctional calmodulin-dependent protein kinase from the brain phosphorylated brain glycogen synthase with concomitant inactivation of the enzyme. Although about 1.3 mol of phosphate/mol subunit was maximally incorporated into glycogen synthase, 0.4 mol of phosphate/mol subunit was sufficient for the maximal inactivation of the enzyme. The results indicate that brain glycogen synthase is regulated in a calmodulin-dependent manner similarly to the skeletal muscle enzyme, but that the brain enzyme is different from the skeletal muscle enzyme.
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
November 1984,
Archives of biochemistry and biophysics,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
September 1983,
FEBS letters,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
November 1983,
FEBS letters,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
October 2000,
Proceedings of the National Academy of Sciences of the United States of America,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
September 1980,
The Journal of biological chemistry,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
May 1984,
FEBS letters,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
April 1986,
Biochimica et biophysica acta,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
June 1979,
Proceedings of the National Academy of Sciences of the United States of America,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
June 1983,
The Journal of biological chemistry,
N Inoue, and
T Iwasa, and
K Fukunaga, and
Y Matsukado, and
E Miyamoto
January 1983,
Methods in enzymology,
