Biomaterial Database

Improving glomerular filtration rate estimation. 2019

Andrew S Levey, and Lesley A Inker

Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address: alevey@tuftsmedicalcenter.org.

Glomerular filtration rate (GFR) estimating equations are widely used, but their accuracy is limited by the need for race-ethnicity factors and imprecision of the estimated GFR. In this issue, Bukabau et al. evaluated the accuracy of GFR estimating equations and race-ethnicity factors in 2 centers in sub-Saharan Africa. The authors determined that the African American factor is not applicable and that newer equations are not more accurate than the Chronic Kidney Disease Epidemiology Collaboration equations recommended by current guidelines.

UI	MeSH Term	Description	Entries
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D051436	Renal Insufficiency, Chronic	Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)	Kidney Insufficiency, Chronic,Chronic Kidney Diseases,Chronic Kidney Insufficiency,Chronic Renal Diseases,Chronic Renal Insufficiency,Chronic Kidney Disease,Chronic Kidney Insufficiencies,Chronic Renal Disease,Chronic Renal Insufficiencies,Disease, Chronic Kidney,Disease, Chronic Renal,Diseases, Chronic Kidney,Diseases, Chronic Renal,Kidney Disease, Chronic,Kidney Diseases, Chronic,Kidney Insufficiencies, Chronic,Renal Disease, Chronic,Renal Diseases, Chronic,Renal Insufficiencies, Chronic
D055316	Cystatin C	An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.	Cystatin 3,Neuroendocrine Basic Polypeptide,Post-gamma-Globulin,gamma-Trace,Basic Polypeptide, Neuroendocrine,Post gamma Globulin,gamma Trace
D017954	Africa South of the Sahara	All of Africa except Northern Africa (AFRICA, NORTHERN) including ANGOLA; BENIN; BOTSWANA; BURKINA FASO; CABO VERDE; CAMEROON; CENTRAL AFRICAN REPUBLIC; CHAD; CONGO; COTE D'IVOIRE; DEMOCRATIC REPUBLIC OF THE CONGO; DJIBOUTI; EQUATORIAL GUINEA; ERITREA; ESWATINI; ETHIOPIA; GABON; GAMBIA; GHANA; GUINEA; GUINEA-BISSAU; KENYA; LESOTHO; LIBERIA; MALAWI; MALI; MAURITANIA; MOZAMBIQUE; NAMIBIA; NIGER; NIGERIA; RWANDA; SAO TOME AND PRINCIPE; SENEGAL; SIERRA LEONE; SOMALIA; SOUTH AFRICA; SOUTH SUDAN; SUDAN; TANZANIA; TOGO; UGANDA; ZAMBIA; and ZIMBABWE.	Africa, Sub-Saharan,Sub-Saharan Africa,Subsaharan Africa