BIOMAT Database Logo BIOMAT Database Logo

Exchange Transfusion and Cytarabine for Transient Abnormal Myelopoiesis in Hydrops Fetalis. 2019

Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D003561 Cytarabine A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472) Ara-C,Arabinofuranosylcytosine,Arabinosylcytosine,Cytosine Arabinoside,Aracytidine,Aracytine,Cytarabine Hydrochloride,Cytonal,Cytosar,Cytosar-U,beta-Ara C,Ara C,Arabinoside, Cytosine,Cytosar U,beta Ara C
D004314 Down Syndrome A chromosome disorder associated either with an extra CHROMOSOME 21 or an effective TRISOMY for chromosome 21. Clinical manifestations include HYPOTONIA, short stature, BRACHYCEPHALY, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, single transverse palmar crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213) Mongolism,Trisomy 21,47,XX,+21,47,XY,+21,Down Syndrome, Partial Trisomy 21,Down's Syndrome,Partial Trisomy 21 Down Syndrome,Trisomy 21, Meiotic Nondisjunction,Trisomy 21, Mitotic Nondisjunction,Trisomy G,Downs Syndrome,Syndrome, Down,Syndrome, Down's
D005078 Exchange Transfusion, Whole Blood Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000964 Antimetabolites, Antineoplastic Antimetabolites that are useful in cancer chemotherapy. Antineoplastic Antimetabolites
D015160 Hydrops Fetalis Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS. Edema, Fetal,Fetal Edema,Fetal Hydrops,Familial Non-Immune Hydrops Fetalis,Hydrops Fetalis Nonimmune,Hydrops Fetalis, Idiopathic,Hydrops Fetalis, Immune,Hydrops Fetalis, Non-Immune,Hydrops Fetalis, Nonimmune,Idiopathic Hydrops Fetalis,Immune Hydrops Fetalis,Non-Immune Hydrops Fetalis,Familial Non Immune Hydrops Fetalis,Fetali, Idiopathic Hydrops,Fetalis Nonimmune, Hydrops,Fetalis Nonimmunes, Hydrops,Fetalis, Idiopathic Hydrops,Hydrops Fetali, Idiopathic,Hydrops Fetali, Nonimmune,Hydrops Fetalis Nonimmunes,Hydrops, Fetal,Idiopathic Hydrops Fetali,Nonimmune Hydrops Fetali,Nonimmune Hydrops Fetalis,Nonimmune, Hydrops Fetalis,Nonimmunes, Hydrops Fetalis
D038042 Myelopoiesis Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.

Related Publications

Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis?
May 2019, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Transient abnormal myelopoiesis associated with Down syndrome presenting as severe hydrops fetalis: a case report.
January 2010, Fetal diagnosis and therapy,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Exchange transfusion for erythroblastosis fetalis.
September 1953, Rocky Mountain medical journal,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Exchange transfusion for erythroblastosis fetalis.
February 1948, The Journal of the Indiana State Medical Association,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Hydrops fetalis due to abnormal lymphatics.
February 1987, Archives of disease in childhood,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Hydrops fetalis due to abnormal lymphatics.
May 1988, Archives of disease in childhood,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Exchange transfusion in erythroblastosis fetalis.
October 1952, The Journal of the Florida Medical Association. Florida Medical Association,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Osteopenia, abnormal dentition, hydrops fetalis and communicating hydrocephalus.
October 1995, Clinical genetics,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Basophilic differentiation in transient abnormal myelopoiesis.
August 2016, American journal of hematology,
Tomoka Okamura, and Yousuke Washio, and Junko Yoshimoto, and Kazumasa Tani, and Hirokazu Tsukahara, and Akira Shimada
Transient abnormal myelopoiesis in Noonan syndrome.
December 2002, Journal of pediatric hematology/oncology,
Copied contents to your clipboard!