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We evaluated the clinical and metabolic effects of a new triphasic regimen developed in the continuing attempt to reduce the dose of estrogen and progestogen in oral contraceptives. A combination of ethinyl estradiol (EE) and levonorgestrel (LNg) was used (six tablets with 30 micrograms EE + 50 micrograms LNg, five tablets with 40 micrograms EE + 75 micrograms LNg, and 10 tablets with 30 micrograms EE + 125 micrograms LNg), also known as Triphasil (Wyeth). In a private practice, 409 subjects participated in 7,286 treatment cycles. Three pregnancies occurred, all due to subject failure. Menstrual regulation was excellent and the incidence of side effects extremely low. Withdrawals from the study for possibly drug-related medical reasons totaled 9.0% through 56 cycles of treatment. Metabolic changes also were evaluated in 14 of these women over a 6-month period. The only statistically significant increase in carbohydrate values occurred at 6 months. The mean glucose level at 30 minutes of the oral glucose tolerance test was above the baseline mean value, but serum insulin levels showed no statistically significant deviation. Lipid values presented are total lipids, total cholesterol, triglycerides, alpha-, beta-, and pre-beta-lipoproteins, and high density and low density lipoprotein cholesterol. There was no statistically significant difference between the mean values at baseline and those during treatment for any lipid variable. These results indicate that this triphasic oral contraceptive has a high degree of efficacy, a low incidence of side effects, excellent cycle control, and high subject compliance, and would seem to indicate a minimal influence on the metabolism of lipids and carbohydrates in the small number of subjects studied.
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
May 1985,
The Medical letter on drugs and therapeutics,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
January 1986,
International journal of fertility,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
January 1985,
Clinical therapeutics,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
January 1992,
Acta obstetricia et gynecologica Scandinavica. Supplement,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
January 1982,
British medical journal (Clinical research ed.),
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
February 1982,
British medical journal (Clinical research ed.),
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
July 1984,
The Journal of reproductive medicine,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
March 1987,
Fertility and sterility,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
October 1985,
Drug and therapeutics bulletin,
H S Ellsworth, and
R I Ayerst, and
J W Harris, and
R A Stone, and
A E Anderson, and
T L Jones, and
M K Curtis
January 1984,
Acta obstetricia et gynecologica Scandinavica,
