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Using synthetic oligomers we investigated fresh samples of acute myeloid leukemia (AML) for the presence of mutated ras oncogenes. Our original results showed that five of eight samples contained a mutation in codon 13 of the N-ras gene. In a subsequent study involving 37 samples, we found only one N-ras-13 mutation, and, in addition, mutations in codon 61 of the N-ras gene in four cases and a mutation in codon 12 of the Ki-ras gene in two cases. Amplification of ras genes was not observed. We conclude that in approximately 20% to 25% of AML cases, a mutated ras oncogene is present, predominantly the N-ras gene. The occurrence of mutations does not correlate with the cytological features of the leukemia.
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
April 1998,
Chinese medical journal,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
May 1999,
Blood,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
January 2009,
The Egyptian journal of immunology,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
November 2004,
Haematologica,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
February 1992,
Oncogene,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
March 1992,
International journal of cancer,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
January 1994,
Acta haematologica,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
November 1991,
American journal of hematology,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
August 1989,
Tumori,
J L Bos, and
M Verlaan-de Vries, and
A J van der Eb, and
J W Janssen, and
R Delwel, and
B Löwenberg, and
L P Colly
July 2006,
Leukemia & lymphoma,
