Biomaterial Database

Electrospun CuO-ZnO nanohybrid: Tuning the nanostructure for improved amperometric detection of hydrogen peroxide as a non-enzymatic sensor. 2019

Sahar Daemi, and Shahram Ghasemi, and Ali Akbar Ashkarran

Department of Physics, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.

Hydrogen peroxide (H2O2) is a by-product of some biochemical processes which is catalyzed by enzymes such as glucose oxidase (GOx), cholesterol oxidase (ChoOx), etc and its overproduction in living cells can trigger cancer growth and various diseases. Therefore, H2O2 sensing is of great importance in the determination of diseases as well as industries and environmental health plans. We produced ZnO-CuO nanofibers by electrospinning method for non-enzymatic electrochemical H2O2 sensing. The sensing properties of the carbon paste electrode (CPE) modified with ZnO (0.3 wt%)/CuO (0.7 wt%) nanofibers (named as ZnO3-CuO7) for detection of H2O2 were explored in phosphate-buffered saline (PBS) at pH ∼ 7.4 solution. The ZnO3-CuO7 nanofiber exhibited the lowest charge transfer resistance and the highest electrocatalytic performance among other modified electrodes for detection of H2O2 and considered as an optimized sample. The effect of scan rate and H2O2 concentration in the reduction process were also investigated by cyclic voltammetry (CV) and the mechanism for the electrochemical reaction of H2O2 at the surface of the optimized electrode was studied. The diffusion coefficient of H2O2 and the catalytic rate constant were evaluated by chronoamperometry as 1.65 × 10-5 cm2 s-1 and 6 × 103 cm3 mol-1 s-1, respectively. Furthermore, amperometric detection of H2O2 with a low detection limit of 2.4 µM and a wide linear range of 3 to 530 µM were obtained. Meanwhile, the optimized electrode displayed no recognizable response towards some biomolecules such as ascorbic acid, uric acid, dopamine and glucose. The obtained results confirmed that the modified electrode shows high sensitivity and selectivity as a H2O2 biosensor with improved reproducibility and stability.

UI	MeSH Term	Description	Entries
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004566	Electrodes	Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.	Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D006861	Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.	Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D012680	Sensitivity and Specificity	Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	Specificity,Sensitivity,Specificity and Sensitivity
D013499	Surface Properties	Characteristics or attributes of the outer boundaries of objects, including molecules.	Properties, Surface,Property, Surface,Surface Property
D015034	Zinc Oxide	A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	Lassar's Paste,Lassar Paste,Lassars Paste,Oxide, Zinc,Paste, Lassar's
D015203	Reproducibility of Results	The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.	Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015374	Biosensing Techniques	Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.	Bioprobes,Biosensors,Electrodes, Enzyme,Biosensing Technics,Bioprobe,Biosensing Technic,Biosensing Technique,Biosensor,Electrode, Enzyme,Enzyme Electrode,Enzyme Electrodes,Technic, Biosensing,Technics, Biosensing,Technique, Biosensing,Techniques, Biosensing
D055664	Electrochemical Techniques	The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.	Electrochemical Technics,Electrochemical Technic,Electrochemical Technique,Technic, Electrochemical,Technics, Electrochemical,Technique, Electrochemical,Techniques, Electrochemical
D057139	Nanofibers	Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.	Nanofiber