Biomaterial Database

Phase transition and release kinetics of polyphenols encapsulated lyotropic liquid crystals. 2019

Heng Zhang, and Zhongni Wang

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, PR China.

In this paper, the lyotropic liquid crystals formed in SL/IP/H2O system were prepared as a drug carrier system to encapsulate polyphenols. The components and introduction of drug had influences in the structure and rheological properties of lyotropic liquid crystals. The structure underwent a phase transition from lamellar phase (Lα) to Lα + HII (reverse hexagonal phase) mixed phases and micelle by increasing its IP/H2O mass ratio from 5/35 to 20/20 and 35/5, consistent with the transition from solid-like properties to viscous fluid properties. For the Lα + HII phase, the loading of DMY induced the structural transition to the HII phase, confirmed by SAXS results. This may be due to the penetration of DMY into the hydrophobic tails of surfactants. The in vitro release kinetic resulted that the release of drug in Lα was associated with diffusional mass transport and matrix swelling. While the release behavior of DMY in HII phase was predominantly controlled by concentration diffusion. These relationships among structure, rheology and release kinetics should be conductive to further design the drug sustained carrier system formed by lyotropic liquid crystals.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D012212	Rheology	The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.	Flowmetry,Velocimetry,Velocimetries
D014783	Viscosity	The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Viscosities
D044367	Phase Transition	A change of a substance from one form or state to another.	Gas-Liquid-Solid Phase Transitions,Sol-Gel Phase Transition,Gas Liquid Solid Phase Transitions,Gas-Liquid-Solid Phase Transition,Phase Transition, Gas-Liquid-Solid,Phase Transition, Sol-Gel,Phase Transitions,Phase Transitions, Gas-Liquid-Solid,Phase Transitions, Sol-Gel,Sol Gel Phase Transition,Sol-Gel Phase Transitions,Transition, Gas-Liquid-Solid Phase,Transition, Sol-Gel Phase,Transitions, Gas-Liquid-Solid Phase,Transitions, Sol-Gel Phase
D050866	Liquid Crystals	Materials in intermediate state between solid and liquid.	Liquid Crystalline Materials,Mesomorphous Phase Materials,Crystal, Liquid,Crystals, Liquid,Liquid Crystal,Material, Mesomorphous Phase,Materials, Mesomorphous Phase,Mesomorphous Phase Material
D053838	Scattering, Small Angle	Scattering of a beam of electromagnetic or acoustic RADIATION, or particles, at small angles by particles or cavities whose dimensions are many times as large as the wavelength of the radiation or the de Broglie wavelength of the scattered particles. Also know as low angle scattering. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Small angle scattering (SAS) techniques, small angle neutron (SANS), X-ray (SAXS), and light (SALS, or just LS) scattering, are used to characterize objects on a nanoscale.	Small Angle Scattering,Low Angle Scattering,Scattering, Low Angle,Angle Scattering, Low,Angle Scatterings, Low,Low Angle Scatterings,Scatterings, Low Angle
D059808	Polyphenols	A large class of organic compounds having more than one PHENOL group.	Polyphenol,Provinols
D065546	Drug Liberation	Release of drugs from DOSAGE FORMS into solution.	Drug Dissolution,Drug Release,Dissolution, Drug,Liberation, Drug,Release, Drug