-transparent.png){kind=logo}
A post-antimicrobial effect (PAE) was seen with all of the new 4-quinolones studied: ciprofloxacin, ofloxacin, Cl-934, Ro 23-6240, A-56619 and S-25930. The post-antimicrobial suppression of growth was for 4-8 h in the case of Escherichia coli, Klebsiella pneumoniae, Serratia marcescens and Pseudomonas aeruginosa. PEA was demonstrated both in Mueller-Hinton broth at pH 7.4 and in urine at pH 5.5 with a Mg2+ concentration of 9.5 mM. Resistant organisms, with MICs greater than 4 micrograms/ml, showed a PAE after a 2-h exposure to 200 micrograms/ml of 4-quinolones. This demonstrates that PAE is seen for 4-quinolones even under conditions in which they are less active.
Related Publications
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
January 1992,
Annual review of medicine,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
May 1995,
Journal of toxicology and environmental health,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
March 1992,
Chest,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
December 1989,
The American journal of medicine,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
October 1991,
Die Pharmazie,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
January 1988,
Reviews of infectious diseases,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
November 1996,
Nihon rinsho. Japanese journal of clinical medicine,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
December 1989,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
January 1986,
European journal of respiratory diseases. Supplement,
H C Neu, and
T Kumada, and
N X Chin, and
W Mandell
February 1989,
Clinical and investigative medicine. Medecine clinique et experimentale,
