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Twenty type II (non-insulin-dependent) poorly controlled diabetics had tests of coagulation and platelet function performed while receiving high-dose sulphonylurea therapy and at 1 and 3 months following their conversion to insulin. Although no overall change in glycaemic control (assessed by glycosylated haemoglobin) was noted, a reduction in thrombin generation was observed, as judged by a significant fall in fibrinopeptide A concentrations. No changes in factor VIII coagulant activity (VIII:C), factor VIII-related antigen or antithrombin III were found. Glycosylated haemoglobin concentrations showed significant correlations with antithrombin III and factor VIII:C, suggesting that improved glycaemic control might lead to an improvement of antithrombin III function and lower factor VIII:C concentrations. No changes in platelet function were detected. The introduction of an insulin regimen that improves glycaemic control might lead to a reversal of the 'hypercoagulable state' found in type II diabetes.
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
March 1993,
The Nursing clinics of North America,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
December 1991,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
July 1982,
Clinics in endocrinology and metabolism,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
January 1985,
Advances in experimental medicine and biology,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
January 1996,
Annual review of medicine,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
April 1993,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
October 1987,
Atherosclerosis,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
January 1990,
Zeitschrift fur arztliche Fortbildung,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
September 2021,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
M Small, and
J T Douglas, and
G D Lowe, and
A C MacCuish, and
C D Forbes
March 1985,
Experientia,
