Circulating immune complexes in systemic lupus erythematosus. Association with other immunologic abnormalities but not with changes in renal function. 1978

K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup

In a study of the usefulness of two widely performed tests for immune complexes (IC) in the assessment of disease activity of lupus nephritis the Raji cell assay detected IC in sera of 14 of 32 patients and the monoclonal rheumatoid factor (MRF) test in only five. There was a close correlation of levels of IC with number of organ systems showing disease activity and with serum complement levels and a somewhat less significant correlation with serum levels of anti-DNA. Although in a few patients levels of IC closely paralleled improvement in renal function with treatment, there was no overall correlation of changes of levels of IC with changes in creatinine clearance. Measurement of circulating IC in lupus nephritis cannot at present be justified as a worthwhile clinical measurement in the management of such patients.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003181 Complement C4 A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B. C4 Complement,C4 Complement Component,Complement 4,Complement C4, Precursor,Complement Component 4,Pro-C4,Pro-complement 4,C4, Complement,Complement Component, C4,Complement, C4,Component 4, Complement,Component, C4 Complement,Pro C4,Pro complement 4
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
January 1982, Medicina clinica,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
August 1977, Clinical and experimental immunology,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
January 1989, Terapevticheskii arkhiv,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
October 1988, Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
January 1982, Terapevticheskii arkhiv,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
April 1971, Fysiatricky a reumatologicky vestnik,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
May 1979, The Journal of experimental medicine,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
April 1984, Immunitat und Infektion,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
January 2000, Lupus,
K A Huston, and R C Gupta, and J V Donadio, and F C McDuffie, and D M Ilstrup
January 1982, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Copied contents to your clipboard!