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The effects of anti-inflammatory steroids and BW-755C (both of which inhibit the formation of prostaglandins and leukotrienes) were studied in ischemia-induced edema and necrosis of the rabbit ear utilizing an occlusion reperfusion model. The results were compared with cyclooxygenase inhibitors which selectively block the synthesis of prostaglandins without affecting leukotriene production. Significant inhibition of the progression of necrosis was observed with both methyl prednisolone and BW-755C. The cyclooxygenase inhibitors, naproxen and low-dose indomethacin had no effect on the progression of ear necrosis. By contrast, high-dose indomethacin significantly inhibited edema but accelerated the progression of necrosis.
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
November 1985,
The American review of respiratory disease,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
February 1986,
Thrombosis research,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
January 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
March 1988,
Annals of the rheumatic diseases,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
August 1994,
Journal of applied physiology (Bethesda, Md. : 1985),
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
February 1988,
Biochemical and biophysical research communications,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
October 1980,
Prostaglandins,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
December 1986,
Prostaglandins, leukotrienes, and medicine,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
June 1991,
Scandinavian journal of clinical and laboratory investigation,
B Hayden, and
R Soderberg, and
H Zarem, and
G Chaudhuri
February 1980,
FEBS letters,
