-transparent.png){kind=logo}
Chimeric genes were constructed which gave rise to the expression of novel receptor molecules consisting of the extracellular domain of the human interleukin 2 receptor (IL-2-R; p55 or Tac antigen) joined to the transmembrane domain and either full-length or truncated cytoplasmic domain of the human insulin receptor (Ins-R). Expression studies using mouse T cell line EL-4 revealed that the chimeric receptors are able to manifest properties indistinguishable from the authentic IL-2-R. On the other hand, stimulation of the tyrosine kinase activity by IL-2 was not observed in the chimeric receptor with the entire cytoplasmic domain of the Ins-R. These findings thus shed light on the structural conformation and functioning of the IL-2-R complex.
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
December 1986,
Proceedings of the National Academy of Sciences of the United States of America,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
December 2002,
The Journal of biological chemistry,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
October 1993,
Seminars in immunology,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
May 1991,
The EMBO journal,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
August 1991,
Journal of interferon research,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
October 1989,
Biochemical and biophysical research communications,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
June 1991,
Proceedings of the National Academy of Sciences of the United States of America,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
September 2015,
Biochemistry,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
October 2000,
Biochemistry,
M Hatakeyama, and
T Doi, and
T Kono, and
M Maruyama, and
S Minamoto, and
H Mori, and
M Kobayashi, and
T Uchiyama, and
T Taniguchi
February 1993,
Biochemical and biophysical research communications,
