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253 patients were treated for 3 years with 400 mg cimetidine at night to prevent relapses of recently healed duodenal ulcers. The efficacy of maintenance treatment was evaluated on a life table basis. In contrast to previous studies not the first but the third symptomatic relapse was taken as the major criterium of treatment failure, an assumption, that better represents the everyday practical situation. Further endpoints for the life table calculation were: the wish of the patient to stop treatment after the first or second recurrence, the failure of a first or second recurrence to heal within 12 weeks and side effects. At 1, 2 and 3 years 5 +/- 2.4%, 16 +/- 4.6% and 20 +/- 5.2% respectively had to be considered as treatment failures. 4 patients presented with a bleeding relapse, none of which necessitated emergency operation. There were no irreversible side effects. This study demonstrates that treatment of recurrent duodenal ulcers with 400 mg cimetidine at night for 3 years is safe and improves considerably the quality of life of the majority of patients. The authors suggest that drug maintenance treatment should be offered before surgery is recommended.
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
January 1983,
Fortschritte der Medizin,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
November 1978,
Zeitschrift fur Gastroenterologie,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
July 1981,
Medizinische Klinik,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
January 1985,
Minerva dietologica e gastroenterologica,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
January 1986,
Scandinavian journal of gastroenterology. Supplement,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
November 1980,
The Medical journal of Australia,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
June 1979,
Digestive diseases and sciences,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
April 1991,
Alimentary pharmacology & therapeutics,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
January 1979,
Revista do Hospital das Clinicas,
E Hentschel, and
G Brandstätter, and
G Judmaier, and
E Kerstan, and
P Kratochvil, and
W Reichel, and
E Rüdiger, and
K Schütze, and
W Weiss
January 1985,
Minerva dietologica e gastroenterologica,
