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The presence of neuron-specific enolase (NSE) and S-100 protein, which are nerve specific proteins, was immunohistochemically investigated on the cutaneous nerves. NSE was found in the axons of the cutaneous nerve bundles and the terminal axons in the Meissner and Pacinian corpuscles of the normal human and macaque skin. S-100 protein was found in the Schwann cells, lamellar cells of the Meissner corpuscles, and inner core cells of the Pacinian corpuscles. After denervation of the ulnar nerve on macaque, NSE on axons of the cutaneous nerves and Meissner and Pacinian corpuscles was completely disappeared in the 5th digit. However, S-100 protein was still maintained in the Schwann cells and Meissner and Pacinian corpuscles in the same digit. From these results, we conclude that the comparative immunohistochemical staining of NSE and S-100 protein is simple and reliable method to demonstrate the cutaneous nerves in normal and pathological conditions.
H Hachisuka, and
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Y Sasai, and
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H Uno
January 1985,
Virchows Archiv. A, Pathological anatomy and histopathology,
H Hachisuka, and
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H Uno
May 1986,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
H Hachisuka, and
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H Uno
September 1983,
Brain research,
H Hachisuka, and
F Sakamoto, and
O Mori, and
H Nomura, and
Y Sasai, and
Y Nakamura, and
H Uno
January 1983,
Virchows Archiv. A, Pathological anatomy and histopathology,
H Hachisuka, and
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H Nomura, and
Y Sasai, and
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H Uno
January 1984,
Cell and tissue research,
H Hachisuka, and
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H Nomura, and
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H Uno
November 1988,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
H Hachisuka, and
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H Uno
July 1985,
American journal of clinical pathology,
H Hachisuka, and
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H Uno
January 1987,
Acta pathologica japonica,
H Hachisuka, and
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January 1985,
Medicina,
H Hachisuka, and
F Sakamoto, and
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H Nomura, and
Y Sasai, and
Y Nakamura, and
H Uno
June 1988,
Pathology, research and practice,
