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Tissue changes were examined in detail via computerised tomography (matrix 160 X 160) in 28 patients with neurologically established encephalomyelitis disseminata. In the majority of cases, demyelinisation was not characteristic of the predominant pathologico-anatomical substrate, ventricular extension with diffuse atrophy but without demyelinisation being the leading sign. However, if the disseminated disease became manifest with foci of demyelinisation, these presented a preferably periventricular pattern.
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