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Thirteen dogs were entered into a pilot study to assess the toxicities associated with polyamine biosynthetic enzyme inhibitors as heat sensitizing drugs and whole body hyperthermia either alone or in combination. Disease-free and tumour-bearing animals were entered in an effort to assess the response of canine lymphoproliferative disorders as well. Conclusions reached were as follows. (1) A large tumour burden precludes treatment. (2) Liver involvement and decreased platelet numbers would appear to offer a grave prognosis for survival and should be assessed closely in determining eligibility. (3) Polyamine biosynthetic enzyme inhibitors and whole body hyperthermia appear to be tumoricidal alone or in combination, although less effective and with greater toxicities than accepted chemotherapeutic regimens. (4) Heat sensitization in vivo has not yet been demonstrated.
M K Klein, and
M W Dewhirst, and
D J Fuller
January 1980,
Annals of the New York Academy of Sciences,
M K Klein, and
M W Dewhirst, and
D J Fuller
June 2001,
European journal of cancer (Oxford, England : 1990),
M K Klein, and
M W Dewhirst, and
D J Fuller
May 1994,
Cancer letters,
M K Klein, and
M W Dewhirst, and
D J Fuller
August 1999,
Veterinary immunology and immunopathology,
M K Klein, and
M W Dewhirst, and
D J Fuller
February 1990,
Urology,
M K Klein, and
M W Dewhirst, and
D J Fuller
March 1990,
Medical & biological engineering & computing,
M K Klein, and
M W Dewhirst, and
D J Fuller
January 2006,
Biofizika,
M K Klein, and
M W Dewhirst, and
D J Fuller
March 1996,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
M K Klein, and
M W Dewhirst, and
D J Fuller
November 1995,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
M K Klein, and
M W Dewhirst, and
D J Fuller
January 2003,
Pflege Zeitschrift,
