BIOMAT Database Logo BIOMAT Database Logo

Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine. 1979

R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou

UI MeSH Term Description Entries
D007153 Immunologic Deficiency Syndromes Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. Antibody Deficiency Syndrome,Deficiency Syndrome, Immunologic,Deficiency Syndromes, Antibody,Deficiency Syndromes, Immunologic,Immunologic Deficiency Syndrome,Immunological Deficiency Syndromes,Antibody Deficiency Syndromes,Deficiency Syndrome, Antibody,Deficiency Syndrome, Immunological,Deficiency Syndromes, Immunological,Immunological Deficiency Syndrome,Syndrome, Antibody Deficiency,Syndrome, Immunologic Deficiency,Syndrome, Immunological Deficiency,Syndromes, Antibody Deficiency,Syndromes, Immunologic Deficiency,Syndromes, Immunological Deficiency
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D009700 Nucleoside Deaminases Catalyze the hydrolysis of nucleosides with the elimination of ammonia. Deaminases, Nucleoside
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003839 Deoxyadenosines Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule. Adenine Deoxyribonucleosides,Adenylyldeoxyribonucleosides,Deoxyadenosine Derivatives,Deoxyribonucleosides, Adenine,Derivatives, Deoxyadenosine
D003841 Deoxycytidine A nucleoside component of DNA composed of CYTOSINE and DEOXYRIBOSE. Cytosine Deoxyribonucleoside,Cytosine Deoxyriboside,Deoxyribonucleoside, Cytosine,Deoxyriboside, Cytosine
D000241 Adenosine A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. Adenocard,Adenoscan
D000243 Adenosine Deaminase An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA. Adenosine Aminohydrolase,Aminohydrolase, Adenosine,Deaminase, Adenosine
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent

Related Publications

R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Effects of deoxyadenosine on ribonucleotide reductase in adenosine deaminase-deficient lymphocytes.
January 1991, Journal of inherited metabolic disease,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Inhibition of 3H-thymidine incorporation by adenosine and deoxyadenosine in human peripheral lymphocytes and malignant lymphoid cell lines.
January 1986, Advances in experimental medicine and biology,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells.
May 1984, Biochimica et biophysica acta,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Immunoreconstitution by peripheral blood leukocytes in adenosine deaminase-deficient severe combined immunodeficiency.
August 1980, The Journal of clinical investigation,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
The combination of adenosine deaminase inhibition and deoxyadenosine induces apoptosis in a human astrocytoma cell line.
January 2015, Neurochemistry international,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Nucleotide levels and metabolism of adenosine and deoxyadenosine in intact erythrocytes deficient in adenosine deaminase.
January 1984, Advances in experimental medicine and biology,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Increased level of ribonucleotide reductase in deoxyadenosine resistant adenosine deaminase deficient human histiocytic lymphoma cells.
January 1986, Advances in experimental medicine and biology,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Increased purine nucleotides in adenosine deaminase-deficient lymphocytes.
July 1977, The Journal of pediatrics,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
Protection by various deoxynucleosides against deoxyadenosine-induced DNA damage in adenosine deaminase-inactivated lymphocytes.
December 1999, Molecular genetics and metabolism,
R Hirschhorn, and S Bajaj, and W Borkowsky, and A Kowalski, and R Hong, and A Rubinstein, and P Papageorgiou
In vivo and in vitro effects of thymosin and adenosine deaminase on adenosine-deaminase-deficient lymphocytes.
February 1979, The New England journal of medicine,
Copied contents to your clipboard!