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The hepatocarcinogenic potencies of three newly identified hydroxymethyl derivatives of 4-(N,N-dimethylamino)azobenzene [(DAB) CAS: 60-11-7], i.e., 2'-CH2OH-DAB, 3'-CH2OH-DAB, and 4'-CH2OH-DAB, were strictly evaluated in a long-term test (400 days) and compared to the potency of 3'-CH3-DAB. ACI/N rats, known to be less sensitive to azo dye carcinogenesis, were given one of these compounds in their diets for 120 days. The incidence of hepatocellular carcinoma in group 2 (20/20), which was given 3'-CH2OH-DAB, was much higher than that in any of the other groups: group 1 (2'-CH2OH-DAB; 4/19), group 3 (4'-CH2OH-DAB; 1/25), or group 4 (3'-CH3-DAB; 3/24). These data suggest that 3'-CH2OH-DAB is the most potent hepatocarcinogen in the series of azo dyes. Possible reasons for the potency of the chemical are discussed.
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
January 1984,
Experimental pathology,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
September 1979,
Radioisotopes,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
February 1981,
Radioisotopes,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
February 1981,
Gan,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
September 1972,
International journal of cancer,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
December 1971,
Gan,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
October 1975,
Gan,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
December 1978,
Gan,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
October 1979,
Laboratory animals,
H Mori, and
T Tanaka, and
S Sugie, and
T Kuniyasu, and
H Iwata, and
H Ni-i, and
A Nishiwaki, and
Y Mori
February 1981,
FEBS letters,
