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A new synthetic substance, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid, is specially cleaved by pancreatic chymotrypsin after oral administration and the released p-aminobenzoic acid (P.A.B.A.) is absorbed and excreted in the urine. The P.A.B.A. recovery in the urine was examined to evaluate its diagnostic value as an exocrine pancreatic function test. The data permit the following conclusions: 1. There is a significant correlation between this test and maximal bicarbonate concentration, amylase output and volume of P.Z./C.C.K. secretin test. 2. More than one-half to two-thirds proximal or one-third distal of the pancreas must be removed before one can expect an abnormal result in this test. 3. This is a simple and useful test to detect exocrine pancreatic insufficiency of more than moderate degree but normal results may be obtained in minimal to mild exocrine pancreatic insufficiency. Only six of 11 cases (54.5%) with one abnormal factor of P-S test showed decreased P.A.B.A. recpvery, whereas 22 of 23 cases (95.7%) with two or three abnormal factors of P-S test showed decreased or borderline P.A.B.A. recovery.
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
March 1976,
Lancet (London, England),
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
January 1980,
Nihon rinsho. Japanese journal of clinical medicine,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
September 1979,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
April 1977,
Lancet (London, England),
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
July 1976,
Lancet (London, England),
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
January 1952,
Revista espanola de las enfermedades del aparato digestivo y de la nutricion,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
April 1977,
La Nouvelle presse medicale,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
April 1982,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
May 1978,
Nihon rinsho. Japanese journal of clinical medicine,
H Harada, and
K Mishima, and
T Shundo, and
N Yamamoto, and
T Sasaki, and
T Hinofuji, and
T Hayashi, and
Y Uchida, and
I Kimura
January 1975,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
