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A previous study has shown that acute administration of the 5-HT2 receptor antagonist ritanserin doubles Slow Wave Sleep (SWS) and increases the prolactin (PRL) response to L-tryptophan (LTP). The present study investigated the effect of repeated ritanserin treatment on sleep, neuroendocrine response to LTP and 5-HT2 platelet receptor binding. After 2 weeks, ritanserin administration SWS was persistently increased but the PRL response to LTP was unchanged. Platelet 5-HT receptor binding was undetectable at the end of ritanserin treatment but recovered 2 weeks after drug withdrawal. The results suggest that ritanserin causes a sustained effect on the 5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors. However, adaptation occurs to its effect on 5-HT-mediated neuroendocrine responses.
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
January 1976,
Monographs in neural sciences,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
January 1986,
Psychopharmacology,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
January 1992,
Psychopharmacology,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
March 1999,
Psychopharmacology,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
January 1982,
Journal of psychiatric research,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
April 1979,
Waking and sleeping,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
January 1978,
Acta neurologica. Quaderni,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
March 1972,
The Journal of pharmacy and pharmacology,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
February 1991,
British journal of clinical pharmacology,
C Idzikowski, and
P J Cowen, and
D Nutt, and
F J Mills
July 2017,
Amino acids,
