-transparent.png){kind=logo}
The testicular toxicity of di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, and of its major metabolite, mono-(2-ethylhexyl) phthalate (MEHP), was assessed after a single dose in rats. Treatment with a single dose of 2.8 g/kg DEHP or 0.8 g/kg MEHP was sufficient to induce testicular atrophy as observed 7 days after dosing. Such a treatment had no effect on plasma FSH levels, and had varying effects on testicular zinc concentrations. After a single dose of 0.8 g/kg MEHP the testicular toxicity was age-dependent, in that only prepubertal rats were susceptible.
Related Publications
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
September 1985,
Archives of toxicology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
March 2016,
Human & experimental toxicology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
August 1995,
Veterinary and human toxicology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
September 1989,
Toxicology and applied pharmacology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
May 1981,
Vox sanguinis,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
February 2010,
Basic & clinical pharmacology & toxicology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
February 1985,
Archives of toxicology,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
February 2012,
Chemosphere,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
February 1985,
Environmental research,
O Teirlynck, and
J M Kaufman, and
M G Bogaert, and
H Roels
March 2007,
Journal of toxicology and environmental health. Part A,
