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Vincamine (Vincapront), the alcaloid isolated from Vinca minor L, was tested in rabbits at three dosages (1 mg/kg, 5 mg/kg, 10 mg/kg i.m.) in an electronystagmographic study. The parameters evaluated were: duration, rate and frequency of the post-rotatory nystagmus and the frequency of the per-rotatory nystagmus. While the post-rotatory nystagmus was found to show a reduction in duration and rate, the frequencies did not respond to vincamine. The 1 mg/kg dose had the strongest effect while that of the 10 mg/kg dose was weakest. As these findings may not be explained by sedative or habituation effects we consider the reduction of the post-rotatory nystagmus as an analogue in animal experiments of the vestibular effect seen in man. The electronystagmographic pattern of action corresponds to that of some other antivertiginous drugs.
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
January 1967,
Farmakologiia i toksikologiia,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
December 1961,
Revue des corps de sante des armees terre, mer, air,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
June 1970,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
May 1964,
The Journal of laryngology and otology,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
April 1967,
Neurology,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
December 1980,
The Journal of laryngology and otology,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
January 1983,
Advances in oto-rhino-laryngology,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
January 1970,
Acta oto-rhino-laryngologica Belgica,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
January 1981,
The Annals of otology, rhinology, and laryngology,
K F Hamann, and
B Bernhold, and
B Sattler, and
L Iatraki
January 1974,
Revue d'oto-neuro-ophtalmologie,
