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Twenty eight male Sprague Dawley rats (aged 3 months) were used in the study. The animals were given feed and water as ad libitum. Sprague dawley rats were randomly divided into 4 groups as 7 rats in each group. Except for the control one, aflatoxin B1 (7.5 μg / 200 g), resveratrol (60 mg / kg) was administered to rats of 3 other groups. At the end of the 16th day, blood, semen and tissue specimens were taken by decapitation under ether anesthesia. When we evaluate the spermatological parameters, it is understood that resveratrol has a statistically significant difference in terms of sperm motility and viability (membrane integrity) compared to the control group and aflatoxin B1 administration groups, indicating a protective effect on spermatological parameters. In terms of pathological parameters - histopathological examination - in the control and resveratrol groups, seminiferous tubules were observed to be in normal structure. In the group treated with aflatoxin, the regular structure of the spermatogenic cells deteriorated and the seminiferous tubules became necrotic and degenerative. In the group treated with Afb1 + res, the decreasing of necrotic and degenerative changes were determined compared with in the group treated with aflatoxin. As immunohistochemical examination, cleaved caspase 3 expression was found to be very low in the control and resveratrol groups. Cleaved caspase 3 expression was severely exacerbated in seminiferous tubules in aflatoxin group but cleaved caspase 3 expression level decreased in Afb1 + res. In the biochemical direction, resveratrol has been shown to inhibit the adverse effects of aflatoxin on antioxidant levels and to show a protective effect. For this purpose, the use of resveratrol with antioxidant activity was investigated in preventing or ameliorating damage to aflatoxin B1. It has been concluded that resveratrol effectively prevent the aflatoxin-induced testicular damage and lipid peroxidation. It has also been shown that resveratrol has protective effects on sperm motility and viability.
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
July 2023,
Foods (Basel, Switzerland),
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
November 1987,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
January 1996,
Advances in experimental medicine and biology,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
November 2014,
Journal of the science of food and agriculture,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
June 1980,
Journal of the National Cancer Institute,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
July 2005,
Environmental toxicology and pharmacology,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
May 1984,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
August 1995,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
October 1987,
Radiation research,
A D Omur, and
B Yildirim, and
Y S Saglam, and
S Comakli, and
M Ozkaraca
December 1991,
Biology of reproduction,
