Biomaterial Database

Oral biopsy and fine needle aspiration biopsy from subcutaneous fat in diagnosis of secondary amyloidosis. 1988

S Sorsa, and R P Happonen, and P Klemi

Rheumatism Foundation Hospital, Heinola, Finland.

The reliability of oral biopsy (OB) and fine needle aspiration biopsy from subcutaneous fat (FNAB) in the diagnosis of secondary amyloidosis was compared using the specimens taken from 124 patients, 107 adults and 17 children, suffering from long lasting rheumatoid diseases. 41 of the patients (33.0%) were shown to be positive for amyloidosis with one or both methods. OB was positive in 28, FNAB in 33, and both methods in 20 patients. In addition, rectal biopsy (RB) was positive in 14 out of 43 cases, where it had been taken. In 3 patients, this method was positive for amyloidosis, although OB and FNAB were negative. Thus, the total number of patients positive for amyloidosis in this study was 44 (35.5%). The mean duration time of the disease was significantly longer in the adult and child patient groups with amyloidosis than in those without amyloidosis. The diagnostic sensitivity of OB was 64%, and that of FNAB 75%. The results speak for the use of FNAB as the first choice method in the diagnosis of secondary amyloidosis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009061	Mouth Mucosa	Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.	Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly