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This paper describes measurements of the aerobic cytotoxicity of 42 nitroaromatic and nitroheterocyclic compounds towards Chinese Hamster cells in vitro. The results of acute and chronic exposure were quantified, and the concentration C required to achieve a standard response estimated. Fitting the data to an equation of the form - log C = b0 + b1E, where E is the one-electron reduction potential, explained 47 and 71 per cent of the variance in the acute and chronic aerobic cytotoxicity respectively. The addition of further terms to the equation, quantifying partition properties, was not statistically significant. The coefficient b1 was similar for both acute and chronic exposure; the dependence of both cytotoxicity and radiosensitization efficiency on reduction potential was also similar. A therapeutic ratio derived from these in vitro measurements showed no dependence on redox or partition properties. The insensitivity of cytotoxicity and radiosensitization properties to variations in molecular structure, other than those which influence redox behaviour, offers exceptional flexibility in developing compounds of improved therapeutic ratio.
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
June 1979,
The British journal of radiology,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
November 1979,
Radiology,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
January 1978,
Strahlentherapie. Sonderbande,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
February 1985,
International journal of radiation oncology, biology, physics,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
June 1978,
The British journal of cancer. Supplement,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
June 1976,
The New England journal of medicine,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
December 1981,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
June 1978,
The British journal of cancer. Supplement,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
June 1981,
International journal of radiation oncology, biology, physics,
G E Adams, and
E D Clarke, and
P Gray, and
R S Jacobs, and
I J Stratford, and
P Wardman, and
M E Watts, and
J Parrick, and
R G Wallace, and
C E Smithen
January 1980,
Cancer clinical trials,
