BIOMAT Database Logo BIOMAT Database Logo

Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs. 2019

Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.

Lower maternal vitamin D status during lactation is a common health problem. The objectives of this study were to investigate the effects of maternal 25-hydroxycholecalciferol (25-OH-D3) supplementation during lactation on maternal and neonatal bone health in a sow model. 32 Large White × Landrace sows were assigned randomly to one of two diets supplemented with 2000 IU/kg vitamin D3 (ND) or 50 μg/kg 25-OH-D3 (25-D). The experiment began on day 107 of gestation and continued until weaning on day 21 of lactation. Maternal 25-OH-D3 supplementation significantly decreased milk n-6:n-3 PUFA ratio, which supported bone formation of piglets. Supplementation with 25-OH-D3 altered bone turnover rate of sows and piglets, as evidenced by higher bone-specific alkaline phosphatase (BALP) concentration in serum. 25-D sows had significantly higher bone density and mechanical properties of tibias and femurs than ND sows. Calcium (Ca) absorption rate was higher in 25-D sows than ND sows, which was caused partially by the increased mRNA expressions of renal 1α-hydroxylase (CYP27B1) and duodenal vitamin D receptor (VDR), transient receptor potential vanilloid 6 (TRPV6), and calcium-binding protein D9k (CaBP-D9k). Maternal 25-OH-D3 supplementation increased tibial and femoral Ca content by up-regulating Ca-related gene expression in kidney (CYP27B1), ileum (VDR and claudin-2), and colon (VDR and CaBP-D9k), thus, activating 1,25-dihydroxyvitamin D3 [1,25-(OH)2-D3]-dependent Ca transport in piglets. In conclusion, improved milk fatty acids and higher mRNA expressions of calcitropic genes triggered by maternal 25-OH-D3 supplementation would be the potential mechanism underlying the positive effects of 25-OH-D3 on maternal and neonatal bone health.

UI MeSH Term Description Entries
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008892 Milk The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals. Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D008903 Minerals Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Mineral
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002112 Calcifediol The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. 25-Hydroxycholecalciferol,25-Hydroxyvitamin D 3,25-Hydroxycholecalciferol Monohydrate,25-Hydroxyvitamin D3,Calcidiol,Calcifediol Anhydrous,Calcifediol, (3 alpha,5Z,7E)-Isomer,Calcifediol, (3 beta,5E,7E)-Isomer,Calderol,Dedrogyl,Hidroferol,25 Hydroxycholecalciferol,25 Hydroxycholecalciferol Monohydrate,25 Hydroxyvitamin D 3,25 Hydroxyvitamin D3,Anhydrous, Calcifediol,Monohydrate, 25-Hydroxycholecalciferol
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002136 Calcium, Dietary Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium. Dietary Calcium

Related Publications

Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Intestinal absorption of 25-hydroxycholecalciferol.
July 1974, Lancet (London, England),
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Effects of maternal 25-hydroxycholecalciferol during the last week of gestation and lactation on serum parameters, intestinal morphology and microbiota in suckling piglets.
December 2020, Archives of animal nutrition,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Enrichment with Lucerne Hay Improves Sow Maternal Behaviour and Improves Piglet Survival.
August 2019, Animals : an open access journal from MDPI,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Lead: intestinal absorption and bone mobilization during lactation.
November 1996, Human & experimental toxicology,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Reducing sow confinement during farrowing and in early lactation increases piglet mortality.
July 2016, Journal of animal science,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
[Phosphorus-calcium metabolism and plasma 25-hydroxycholecalciferol in intestinal malabsorption].
September 1980, Helvetica paediatrica acta,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Effects of maternal ethanol consumption during pregnancy or lactation on intestinal absorption of folic acid in suckling rats.
September 2003, Life sciences,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
[Calcium 47 absorption in alcoholic cirrhosis. Effect of 25 hydroxycholecalciferol].
January 1974, La Nouvelle presse medicale,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Parathyroid glands and bone calcium mobilization by 25-hydroxycholecalciferol.
November 1972, Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research,
Lianhua Zhang, and Jiangxu Hu, and Miao Li, and Qinghui Shang, and Sujie Liu, and Xiangshu Piao
Intestinal calcium absorption of women during lactation and after weaning.
April 1996, The American journal of clinical nutrition,
Copied contents to your clipboard!