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Subcutaneous implantation of demineralized bone matrix induces the local formation of cartilage and bone. In this study we have investigated the influence of adding various growth factors to the implant. Cartilage formation was monitored by measuring collagen II mRNA levels, and bone formation in the implant was assessed from alkaline phosphatase activity and calcium content. Supplements of the platelet-derived growth factor to implants in older rats increased and production of mRNA for collagen II, alkaline phosphatase activity, and the calcium content of the implant, whereas the other growth factors tested were without effect. The data suggest that under some conditions bone induction is submaximal and can be increased by local supplement of platelet-derived growth factor (PDGF). The present observations may have important therapeutic implications in the treatment of nonunions of fractures and impaired bone formation in the aged.
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
September 2005,
The Journal of bone and joint surgery. American volume,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
January 2007,
The Journal of bone and joint surgery. American volume,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
December 2009,
Biomacromolecules,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
January 1991,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
August 2000,
Journal of periodontology,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
March 1992,
Archives of histology and cytology,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
May 2006,
The Angle orthodontist,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
April 2001,
International journal of hematology,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
January 1994,
Atherosclerosis,
R Howes, and
J M Bowness, and
G R Grotendorst, and
G R Martin, and
A H Reddi
September 1984,
Clinical orthopaedics and related research,
