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In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type plasminogen activator (rt-PA) or placebo over 3 hr. The groups at entry were similar. At assessment 21 days later, left ventricular ejection fraction measured both by contrast and radionuclide ventriculography was higher in the rt-PA compared with the placebo group (61 +/- 13%, n = 64, vs 54 +/- 14%, n = 62, contrast, 2p = .006; 52 +/- 13%, n = 66, vs 48 +/- 13%, n = 62 isotope, 2p = .08). This indicates limitation of myocardial infarction by rt-PA.
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
October 1990,
Journal of the American College of Cardiology,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
August 1991,
Zhonghua xin xue guan bing za zhi,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
September 1991,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
April 1988,
Journal of the American College of Cardiology,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
September 1991,
The Canadian journal of cardiology,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
September 1989,
Irish medical journal,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
April 1989,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
May 2001,
European journal of neurology,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
September 2015,
The neurologist,
M O'Rourke, and
D Baron, and
A Keogh, and
R Kelly, and
G Nelson, and
C Barnes, and
J Raftos, and
K Graham, and
K Hillman, and
H Newman
September 1989,
The American journal of cardiology,
