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Iodine-Catalyzed Synthesis of Chiral 4-Imidazolidinones Using α-Amino Acid Derivatives via Dehydrogenative N-H/C(sp3)-H Coupling. 2019

Kyalo Stephen Kanyiva, and Marina Tane, and Takanori Shibata
Global Center of Science and Engineering, School of Advanced Science and Engineering , Waseda University , 3-4-1 Okubo , Shinjuku, Tokyo 169-8555 , Japan.

An efficient method for the asymmetric synthesis of 4-imidazolidinones via an iodine-catalyzed intramolecular N-H/C(sp3)-H activation of readily available and abundant feedstocks, amino acids, and amines is described. The reaction proceeded under visible light irradiation to afford a variety of 4-imidazolidinone derivatives under mild conditions in moderate to excellent yields. Secondary and tertiary C(sp3)-H bonds were aminated, and various functional groups were tolerated.

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