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DNA Translocation through Hybrid Bilayer Nanopores. 2019

Ramkumar Balasubramanian, and Sohini Pal, and Himanshu Joshi, and Anjana Rao, and Akshay Naik, and Manoj Varma, and Banani Chakraborty, and Prabal K Maiti
Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.

Pore functionalization has been explored by several groups as a strategy to control DNA translocation through solid-state nanopores. Here we present a hybrid nanopore system consisting of single-layer graphene and a DNA origami layer to achieve base-selective control of DNA translocation rate through aligned nanopores of the two layers. This is achieved by incorporating unpaired dangling bases called overhangs to the origami near the pore region. Molecular dynamics simulations were used to optimize the design of the origami nanopore and the overhangs. Specifically, we considered the influence of the number and spatial distribution of overhangs on translocation times. The simulations revealed that specific interactions between the overhangs and the translocating single-stranded DNA resulted in base-specific residence times.

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