BIOMAT Database Logo BIOMAT Database Logo

[A comparison of the 7th and 8th edition of the AJCC TNM staging systems for predicting survival in oropharyngeal cancer]. 2019

Y X Zhang, and M B Liu, and H Huang
Department of Otorhinolaryngology Head and Neck Surgery,the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.

Objective:The aim of this study is to evaluate the prognostic value of the 8th edition of AJCC TNM classification in comparison with the 7th edition for oropharyngeal cancer. Method: The clinical and pathological data of 142 patients with oropharyngeal squamous cell carcinoma were retrospectively analyzed. The p16 protein was detected by immunohistochemical staining. Survival and survival analysis were performed using the Kaplan-Meier method and the Log-rank test. Result:The 5-year disease-specific survival（DSS）,the 5-year overall survival (OS) and the median survival time for patients with oropharyngeal cancer were 55.4%,50.4% and 60.3 months, respectively. P16-immunostaining was scored positive in 39 samples (27.5%,39/142).Based on the seventh edition of AJCC staging, there were 4 patients in stage Ⅰ,17 patients in stage Ⅱ,27 patients in stage Ⅲ and 94 patients in stage Ⅳ,respectively.However, there was no significant difference in survival between the patients with stage Ⅰ-Ⅱ and those with Ⅲ-Ⅳ(5-year DSS:75.9% of stage Ⅰ-Ⅱ patients vs. 52.2% of stage Ⅲ-Ⅳ patients;P=0.109).In comparison, 22 patients were diagnosed as stage Ⅰ,24 were stage Ⅱ,27 were stage Ⅲ and 69 were stage Ⅳ using the eighth edition. The 5-year DSS for patients with stage Ⅰ,Ⅱ,Ⅲ and Ⅳ was 88.4%, 80.5%, 73.2% and 29.1%, respectively. The overall difference was statistically significant (P=0.000). Conclusion:Compared with the seventh edition staging, the eighth edition of the AJCC oropharyngeal cancer staging system considers the prognosis of patients with different causes of oropharyngeal cancer, and can more accurately predict the prognosis of patients.

UI MeSH Term Description Entries
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D009959 Oropharyngeal Neoplasms Tumors or cancer of the OROPHARYNX. Cancer of Oropharnyx,Oropharyngeal Cancer,Cancer of the Oropharynx,Neoplasms, Oropharyngeal,Oropharynx Cancer,Oropharynx Neoplasms,Cancer, Oropharyngeal,Cancer, Oropharynx,Cancers, Oropharyngeal,Cancers, Oropharynx,Neoplasm, Oropharyngeal,Neoplasm, Oropharynx,Neoplasms, Oropharynx,Oropharnyx Cancer,Oropharnyx Cancers,Oropharyngeal Cancers,Oropharyngeal Neoplasm,Oropharynx Cancers,Oropharynx Neoplasm
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D015996 Survival Rate The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods. Cumulative Survival Rate,Mean Survival Time,Cumulative Survival Rates,Mean Survival Times,Rate, Cumulative Survival,Rate, Survival,Rates, Cumulative Survival,Rates, Survival,Survival Rate, Cumulative,Survival Rates,Survival Rates, Cumulative,Survival Time, Mean,Survival Times, Mean,Time, Mean Survival,Times, Mean Survival

Related Publications

Y X Zhang, and M B Liu, and H Huang
HPV impact on oropharyngeal cancer radiological staging: 7th vs 8th edition of AJCC TNM classification.
January 2023, Clinical imaging,
Y X Zhang, and M B Liu, and H Huang
Comparison between 7th and 8th edition of AJCC TNM staging system for gastric cancer: old problems and new perspectives.
January 2019, Translational gastroenterology and hepatology,
Y X Zhang, and M B Liu, and H Huang
Survival comparison in gastric cancer patients between 7th and 8th edition of the AJCC TNM staging system: The first western single center experience.
June 2019, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Y X Zhang, and M B Liu, and H Huang
AJCC 8th Edition (2017) versus AJCC 7th Edition (2010) in thin melanoma staging.
September 2018, Neoplasma,
Y X Zhang, and M B Liu, and H Huang
The updated AJCC/TNM staging system (8th edition) for oral tongue cancer.
March 2019, Translational cancer research,
Y X Zhang, and M B Liu, and H Huang
Risk factors for survival of head and neck soft tissue sarcomas: A comparison between 7th and 8th edition AJCC staging systems.
July 2020, Oral oncology,
Y X Zhang, and M B Liu, and H Huang
AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN.
August 2019, World journal of surgical oncology,
Y X Zhang, and M B Liu, and H Huang
The 8th edition AJCC/UICC TNM staging for p16-positive oropharyngeal carcinoma: is there space for improvement?
December 2018, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
Y X Zhang, and M B Liu, and H Huang
Radical (chemo)radiotherapy in oropharyngeal squamous cell carcinoma: Comparison of TNM 7th and 8th staging systems.
April 2020, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
Y X Zhang, and M B Liu, and H Huang
Comparison of 6th, 7th, and 8th editions of the TNM staging in non-small cell lung cancer patients: Validation of the 8th edition of TNM staging.
July 2022, Turk gogus kalp damar cerrahisi dergisi,
Copied contents to your clipboard!