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[Research on antibacterial and antifungal agents. VII. Synthesis of (1-pyrryl)methylquinolines acids]. 1987
G Stefancich, and
F Corelli, and
S Massa, and
R Silvestri, and
S Panico, and
M Artico, and
N Simonetti
Istituto di Chimica Farmaceutica e Tossicologica, Facolta di Farmacia, Università degli Studi di Roma La Sapienza.
Some (1-pyrryl)methyl derivatives of 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid were synthetized by the standard procedure involving Gould-Jacobs and Lappin reactions. The above derivatives were tested microbiologically as nalidixic acid analogs and compared with some clinically useful 4-oxopyridine-3-carboxylic acids (nalidixic acid, pipemidic acid, norfloxacin, enoxacin and ciprofloxacin). Their antibacterial activities were very weak.
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