BIOMAT Database Logo BIOMAT Database Logo

An enhancer factor defect in a mutant Burkitt lymphoma cell line. 1988

W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184, Strasbourg.

RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.

UI MeSH Term Description Entries
D012045 Regulatory Sequences, Nucleic Acid Nucleic acid sequences involved in regulating the expression of genes. Nucleic Acid Regulatory Sequences,Regulatory Regions, Nucleic Acid (Genetics),Region, Regulatory,Regions, Regulatory,Regulator Regions, Nucleic Acid,Regulatory Region,Regulatory Regions
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D004742 Enhancer Elements, Genetic Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter. Enhancer Elements,Enhancer Sequences,Element, Enhancer,Element, Genetic Enhancer,Elements, Enhancer,Elements, Genetic Enhancer,Enhancer Element,Enhancer Element, Genetic,Enhancer Sequence,Genetic Enhancer Element,Genetic Enhancer Elements,Sequence, Enhancer,Sequences, Enhancer
D005802 Genes, MHC Class II Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice. Class II Genes,Genes, Class II,Genes, HLA Class II,MHC Class II Genes,Class II Gene,Gene, Class II
D006681 HLA-D Antigens Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology. Antigens, HLA-D,Class II Human Antigens,HLA-Dw Antigens,Human Class II Antigens,Ia-Like Antigens, Human,Immune Response-Associated Antigens, Human,Immune-Associated Antigens, Human,Immune-Response Antigens, Human,HLA-D,HLA-Dw,Immune Response Associated Antigens, Human,Antigens, HLA D,Antigens, HLA-Dw,Antigens, Human Ia-Like,Antigens, Human Immune-Associated,Antigens, Human Immune-Response,HLA D Antigens,HLA Dw Antigens,Human Ia-Like Antigens,Human Immune-Associated Antigens,Human Immune-Response Antigens,Ia Like Antigens, Human,Immune Associated Antigens, Human,Immune Response Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured

Related Publications

W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
An immunoferritin study of a Burkitt lymphoma cell line harboring EB virus particles.
June 1970, Gan,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
[Studies on a Japanese Burkitt lymphoma. Part 1. Establishment of a Japanese Burkitt lymphoma cell line (author's transl)].
February 1978, [Rinsho ketsueki] The Japanese journal of clinical hematology,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
RALE051: a novel established cell line of sporadic Burkitt lymphoma.
May 2018, Leukemia & lymphoma,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Replication of herpes-type virus in a Burkitt lymphoma cell line.
December 1967, Journal of virology,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.
June 1993, Oncogene,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Cell cycle activation by c-myc in a burkitt lymphoma model cell line.
September 2000, International journal of cancer,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Structure of virus particles extracted from a Burkitt lymphoma cell line.
June 1967, Journal of virology,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Inhibition of homotypic aggregation of a human Burkitt-lymphoma cell line.
December 1987, International journal of cancer,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
[Studies on a Japanese Burkitt lymphoma. Part 2. Serial transplantation of a Japanese Burkitt lymphoma cell line in hamsters (author's transl)].
September 1978, [Rinsho ketsueki] The Japanese journal of clinical hematology,
W Koch, and S Candeias, and J Guardiola, and R Accolla, and C Benoist, and D Mathis
Rituximab sensitizes a Burkitt lymphoma cell line to cell killing by X-irradiation.
November 2009, Radiation and environmental biophysics,
Copied contents to your clipboard!