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Intrathecal administration of 6-hydroxydopamine (6-OHDA) abolished the antinociceptive effects of acute administration of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 1 mg/kg, s.c.) in the hot-plate, tail-flick and shock titration tests of nociception. The antinociceptive effects of 5-MeODMT, abolished by the prior intrathecal 6-OHDA treatment, were restored by intrathecal administration (2 or 1 microgram) of noradrenaline (NA), immediately prior to 5-MeODMT, in all three tests of nociception. Biochemical analysis confirmed severe NA depletions (95 percent loss) in the lumbar and thoracic regions of the spinal and much lesser dopamine depletions (25-35 percent loss). Intrathecal 5,7-dihydroxytryptamine (5,7-DHT) attenuated 5-MeODMT induced antinociception in the tail-flick test and combined NA + 5-MeODMT induced antinociception in the hot-plate and tail-flick tests. Intrathecal administration of 5,7-DHT caused a severe depletion of 5-hydroxytryptamine in the lumbar region of the spinal cord. The present findings demonstrate further the modulatory role of NA upon serotonergic systems in nociception and indicate the necessity of NA availability for induction of 5-MeODMT analgesia.
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
April 1985,
Brain research,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
November 1993,
European journal of pharmacology,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
December 1982,
Neuroscience letters,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
November 1973,
Journal of chromatography,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
February 1985,
Neuroscience letters,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
October 1965,
The Alabama journal of medical sciences,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
October 1986,
British journal of pharmacology,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
January 1987,
Pharmacology & toxicology,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
May 1987,
Biochemical pharmacology,
B G Minor, and
M L Persson, and
C Post, and
G Jonsson, and
T Archer
January 1987,
Psychopharmacology,
