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The impact of infection and inflammation in oncologic 18F-FDG PET/CT imaging. 2019
W Tania Rahman, and
Daniel J Wale, and
Benjamin L Viglianti, and
Danyelle M Townsend, and
Matthew S Manganaro, and
Milton D Gross, and
Ka Kit Wong, and
Domenico Rubello
Nuclear Medicine Division, Department of Radiology, University of Michigan Hospital, Ann Arbor, MI, USA.
Sites of infection and inflammation can be misleading in oncology PET/CT imaging because these areas commonly show 18F-FDG activity. Caution in the interpretation must be taken to avoid the misdiagnosis of malignancy. Utilization of both CT findings as well as patient history can help differentiate benign infectious and inflammatory processes from malignancy, although occasionally additional work-up may be required. This article discusses the mechanism of 18F-FDG uptake in infection and inflammation with illustrative examples.
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