Biomaterial Database

Acute and long-term effect of antihypertensive treatment on exercise induced microalbuminuria in essential hypertension. 1987

C K Christensen, and L R Krusell

Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.

The effects of mild to moderate exercise (450 kpm/min followed by 600 kpm/min, 20 minutes each) on urinary albumin excretion (UAE) were studied with a group of 12 young patients with newly diagnosed essential hypertension. The mean age was 37 years (range 22-45 years) and mean weight 82 kg. During exercise UAE increased significantly from 12.1 microg/min to 16.7 microg/min. Six of the twelve patients were investigated in an acute study with two exercise tests with minimum one week between one of the times metoprolol was given intravenously and the other time was given placebo. In spite of an effective reduction in systolic blood pressure (in mean 23 mmHg during the maximal workload at 600 kpm/min) no significant difference could be seen in UAE. However, a marked decrease in UAE in six patients treated with beta-blocker in a long-term study was seen. Six months after initiating antihypertensive treatment, the baseline systolic blood pressure was reduced by 38 mmHg and UAE by 63%. The maximal exercise induced increased systolic blood pressure level at 600 kpm/min was reduced by 58 mmHg and UAE by 58%. We conclude that UAE both at rest and during exercise may be a sensitive marker of the effectiveness of antihypertensive therapy. UAE is easy to measure and this parameter might be useful in following essential hypertensive patients.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008134	Long-Term Care	Care over an extended period, usually for a chronic condition or disability, requiring periodic, intermittent, or continuous care.	Care, Long-Term,Long Term Care
D008297	Male		Males
D008790	Metoprolol	A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.	Beloc-Duriles,Betaloc,Betaloc-Astra,Betalok,CGP-2175,H 93-26,Lopressor,Metoprolol CR-XL,Metoprolol Succinate,Metoprolol Tartrate,Seloken,Spesicor,Spesikor,Toprol,Toprol-XL,Beloc Duriles,Betaloc Astra,CGP 2175,CGP2175,H 93 26,H 9326,Metoprolol CR XL,Toprol XL
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked