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Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas. 2020
Rodrigo Barquera, and
Francisco Juárez-Nicolás, and
Julio César Martínez-Álvarez, and
Komathi Sree Ponnandai-Shanmugavel, and
Diana Iraíz Hernández-Zaragoza, and
Tannya Verónica Vázquez-Castillo, and
Esteban Arrieta-Bolaños, and
Stephen Clayton, and
Raúl Solís-Martínez, and
Andrea Ortega-Yáñez, and
María Araceli Arrazola-García, and
Alexander Immel, and
Alicia Bravo-Acevedo, and
María Del Rosario Vega-Martínez, and
Gamaliel Benítez-Arvizu, and
Raquel García-Álvarez, and
Virginia Martínez-Bezies, and
Ariadna Escutia-González, and
Vicencio Juárez-Barreto, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: http://www.shh.mpg.de/en.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61 ± 0.58% by ML; 53.16% of Native American haplotypes) and European (26.39 ± 5.05% by ML; 25.86% of European haplotypes), and a less prominent African genetic component (2.00 ± 5.20% by ML; 9.77% of African haplotypes).
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