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Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo. 2020
Rodrigo Barquera, and
Julio César Martínez-Álvarez, and
Alondra Victoria Trejo-Ordoz, and
María de Los Ángeles Pavón-Vargas, and
María Del Rosario Vega-Martínez, and
Esteban Arrieta-Bolaños, and
Stephen Clayton, and
Andrea Ortega-Yáñez, and
Eva Dolores Juárez-Cortés, and
Francisco Juárez-Nicolás, and
Concepción López-Gil, and
Alexander Immel, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
Gamaliel Benítez-Arvizu, and
Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
Rosa María Macías-Medrano, and
Flor Del Rocío Ramos-de la Cruz, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Patricia Méndez-Mani, and
Ariadna Berenice Escutia-González, and
Gustavo Daniel Montiel-Hernández, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: barquera@shh.mpg.de.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 122 Mexicans from the state of Hidalgo living in the city of Pachuca (N = 41) and rural communities (N = 81), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in Hidalgo include eight Native American and one European haplotypes. Admixture estimates revealed that the main genetic components in Hidalgo are Native American (58.93 ± 2.16% by ML; 54.51% of Native American haplotypes) and European (32.49 ± 2.88% by ML; 28.69% of European haplotypes), and a relatively high African genetic component (8.58 ± 0.93% by ML; 6.97% of African haplotypes).
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Julio César Martínez-Álvarez, and
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Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
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Alicia Bravo-Acevedo, and
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Ariadna Berenice Escutia-González, and
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Esteban Arrieta-Bolaños, and
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Andrea Ortega-Yáñez, and
Eva Dolores Juárez-Cortés, and
Francisco Juárez-Nicolás, and
Concepción López-Gil, and
Alexander Immel, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
Gamaliel Benítez-Arvizu, and
Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
Rosa María Macías-Medrano, and
Flor Del Rocío Ramos-de la Cruz, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Patricia Méndez-Mani, and
Ariadna Berenice Escutia-González, and
Gustavo Daniel Montiel-Hernández, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
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Julio César Martínez-Álvarez, and
Alondra Victoria Trejo-Ordoz, and
María de Los Ángeles Pavón-Vargas, and
María Del Rosario Vega-Martínez, and
Esteban Arrieta-Bolaños, and
Stephen Clayton, and
Andrea Ortega-Yáñez, and
Eva Dolores Juárez-Cortés, and
Francisco Juárez-Nicolás, and
Concepción López-Gil, and
Alexander Immel, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
Gamaliel Benítez-Arvizu, and
Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
Rosa María Macías-Medrano, and
Flor Del Rocío Ramos-de la Cruz, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Patricia Méndez-Mani, and
Ariadna Berenice Escutia-González, and
Gustavo Daniel Montiel-Hernández, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
September 2020,
Human immunology,
Rodrigo Barquera, and
Julio César Martínez-Álvarez, and
Alondra Victoria Trejo-Ordoz, and
María de Los Ángeles Pavón-Vargas, and
María Del Rosario Vega-Martínez, and
Esteban Arrieta-Bolaños, and
Stephen Clayton, and
Andrea Ortega-Yáñez, and
Eva Dolores Juárez-Cortés, and
Francisco Juárez-Nicolás, and
Concepción López-Gil, and
Alexander Immel, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
Gamaliel Benítez-Arvizu, and
Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
Rosa María Macías-Medrano, and
Flor Del Rocío Ramos-de la Cruz, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Patricia Méndez-Mani, and
Ariadna Berenice Escutia-González, and
Gustavo Daniel Montiel-Hernández, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
September 2020,
Human immunology,
Rodrigo Barquera, and
Julio César Martínez-Álvarez, and
Alondra Victoria Trejo-Ordoz, and
María de Los Ángeles Pavón-Vargas, and
María Del Rosario Vega-Martínez, and
Esteban Arrieta-Bolaños, and
Stephen Clayton, and
Andrea Ortega-Yáñez, and
Eva Dolores Juárez-Cortés, and
Francisco Juárez-Nicolás, and
Concepción López-Gil, and
Alexander Immel, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
Gamaliel Benítez-Arvizu, and
Agustín Jericó Arriaga-Perea, and
Virginia Martínez-Bezies, and
Rosa María Macías-Medrano, and
Flor Del Rocío Ramos-de la Cruz, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Patricia Méndez-Mani, and
Ariadna Berenice Escutia-González, and
Gustavo Daniel Montiel-Hernández, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Bárbara Novelo-Garza, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
September 2020,
Human immunology,
